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Iterative validation of such laboratory biomarkers in the clinical setting would also result in establishing objective measures of the success or failure of novel interventions for these complications.
As illustrated by Fig. 2, the final APP algorithm was derived following an iterative validation process.
Thus, 2 out of the 3 regions were resolved by de novo contig mapping combined with an iterative validation step.
Such testing could simultaneously simplify the diagnostic algorithm by replacing gene-specific or panel-based tests, remove the need for iterative testing and validation of the results by Sanger sequencing, and decrease the burden on those reviewing cases.
It also supports automatic model generation from existing network definitions and can therefore be used for iterative network building and validation.
Taken together, we (i) present a bipartite Boolean modelling approach that retains contextual activation information, (ii) provide software support for automatic model generation, visualisation and simulation, and (iii) demonstrate its use for iterative model generation and validation.
This is necessary because the method could be susceptible to noise without this procedure, and the computational cost is prohibitive for iterative variable selection during cross-validation.
Model Based Normalization for Iterative 3D PET Reconstruction.
Models for iterative multiattribute procurement auctions.
The Extraordinaires also provides a great opportunity for iterative thinking.
Design validation through usability testing or focus-group sessions enables a product team to determine the degree to which requirements are being met as well as the need for iterative improvement.
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