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Exact(11)
: Significantly different (P <.05) from the value for invasive isolates.
: Not significantly different (P =.13) from the value for invasive isolates.
In order to avoid duplicate data, numbers were only added from the databases of the SIREVA Project (only for invasive isolates) available via the PAHO website, [ 23].
For invasive isolates, PCV7 serotype coverage was 67% among children <60 months of age and 47% among children >60 months (Table 1).
The high and intermediate response groups were enriched for invasive isolates, which induced significantly higher levels of IL1β, TNF, IL10, IL23, and IL12p70 production than did airway isolates.
For invasive isolates, minimal inhibitory concentrations (MICs) for ampicillin and vancomycin were determined using a semiautomated microbroth dilution system (Micronaut, Merlin, Bornheim-Hersel, Germany).
Similar(49)
For the subset of invasive isolates, PVL was significantly associated with aboriginality (p = 0.001), but not significantly associated with age (median 41 vs 45 years, p = 0.378), community acquisition (p = 0.171), IVDU (p = 1.000), surgery (p = 0.433), or length of stay (median 5 vs 7 days, p = 0.300).
Individually, serotypes Ib, II, IV, and V accounted for less than 6% of invasive isolates in infants less than 7 days of age and in infants aged 7 to 90 days.
Overall, PCV7 serotypes accounted for 64.1% of total isolates and 62.7% of invasive isolates.
Accession numbers for pneumococcal sequences used are listed in SI Table S1; the pangenome built from invasive isolates can be found in SI Table S3.
The number of invasive isolates was limited by public availability of WGS samples marked as isolated from blood.
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