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This trial has been designed according to the CONsolidated Standards Of Reporting Trials CONSORTT) statement, 12 and is reported according to the Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) statement 13 and with reference to the Template for Intervention Description and Replication (TIDieR) checklist.
See Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) Checklist (Research Checklist) (Additional file 2).
Five questions were omitted because they are designed for interventional trials.
(MP4 112000 kb) Additional file 2: Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) Checklist.
The optimal design and patient selection for interventional trials in radiogenomics seem trivial at first sight.
The protocol is reported using the appropriate Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) items.
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In Joseph's paper [ 3] it should be noted that the intent of combining stillbirths plus neonatal deaths as a measure of pregnancy outcome for interventional trial is well-intended.
This ongoing paradigm shift in AD definition and diagnosis represents a fundamental basis for redefinition of interventional trials in AD, allowing to specifically focus on preventative measures during very early pathophysiologically confirmed stages of disease.
This suggests that the publication bias for drug trials is more serious than for other interventional trials in China.
Thus, our study is the basis for further interventional trials in this setting in order to optimize ventilatory management.
The technology of proteomic profiling is becoming cheaper and is reaching the stage of clinical feasibility for large interventional trials.
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