Exact(4)
However, these approaches are quite complicated and can achieve substantially lower genomic coverage, making these technologies more suitable for validating findings than for initial discovery [30].
Thus, mass spectrometry is a valuable complementary method for initial discovery of locations of non-synonymous SNPs.
For initial discovery, biomarker panels were developed on the training data set using 102 BC and AT sample pairs.
For initial discovery, biomarker panels were developed on the training data set of 99 BC and 51 HV samples.
Similar(56)
Nonetheless, if combined with an alternative assay for replication of initial discoveries, 450K arrays are the current assay of choice for genome-wide surveys due to their quantitative, robust, and scalable assessment of DNA methylation levels.
We used an RT-PCR panel for our initial discovery experiments and microRNA and microarray chips both for validation of our previously discovered microRNA/mRNA pairings and to expand the available pool of microRNAs to all currently known microRNAs for a comprehensive examination of microRNA/mRNA pairs.
In the current study, the 1,402 stage 1 trios were used for the initial discovery analysis and the 1,182 stage 2 trios were used for the independent replication study.
These hominins fashioned primitive stone implements, which are dubbed the Oldowan industry for their initial discovery in Olduvai Gorge.
The disease, named for its initial discovery as a white fungus growing on bat noses, drains hibernating bats of their energy reserves.
For the initial discovery phase of novel genetic associations, we used a DNA pooling genotyping methodology.
Five patients were selected for an initial discovery cohort based on their unambiguously decreasing BCR/ABL mRNA transcript levels following initial K562/GVAX vaccination.
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