It is important to appreciate that even a significant correlation of, for instance, 16q loss, which is more frequent in lobular breast cancer [ 57], provides limited statistical prediction power for an individual prospective case.
While the average effect on each baby is small and so should not alarm individual prospective parents, for the whole population these small risks add up across millions of people".
In order that physicians make accurate informed decisions about the care for individual patients, larger prospective studies are required in a new population to validate these findings.
In both crops before harvest, the individuals that moved into the fields were adults of better body condition than those remaining in the natural habitat patch, suggesting that long-distance movements were only possible for individuals with high prospective fitness.
In the Czech Republic, the evaluation of CA frequency in PBLs has been included since 1975 in regular medical checkups of workers exposed to selected occupational hazards, making it feasible to identify a cohort of individuals for prospective follow-up for cancer in order to confirm the results of the studies from Nordic countries, Italy, and Taiwan.
Finally, prospective validation of the clinical utility of gene profiling for classification, determination of prognosis, and selection of optimal therapies for individual patients will require large, prospective, multicenter, controlled clinical trials.
Poor sensitivity of SF-36 to individual change was previously observed in an analytical review of health status measures, with confidence intervals unacceptably wide to be of practical use for individual assessment [ 50] and in prospective follow-up of THR patients [ 17], raising concerns about the ability of SF-36 to reliably detect meaningful changes in health status of individuals.
We refine these results by replacing simple cohort averages with estimates from regression models in prospective time, adjusting for individual covariate information and timing of events.
In allogeneic SCT recipients, the value of monitoring CMV-specific T cells for individual patient management should be addressed in further prospective studies.
