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Proline and aminocaproic acid are ideal linkers for increasing the potency and selectivity of heteromeric antimicrobial peptides.
This may have a broader applicability as a general concept for increasing the potency of long-peptide or protein vaccines.
Our investigations across all moieties of the molecule showed that it displays very tight SAR, but there are some possibilities for increasing the potency.
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Several strategies for increasing the DNA vaccine potency have been developed in the last decade.
Not only does she explain that horse-milk needs to be fermented because of its high lactose content, she also includes a recipe for increasing the alcohol content "until the desired potency is reached".
Hence further structural studies are essential to assist drug targeting of Ets TFs in cancer, to increase the scope of Ets surfaces available for inhibition and to increase the potency of existing drugs.
Structure-activity relationship (SAR analysis showed that heterocyclic alkane at the solvent interface position could significantly increase the potency for the inhibition of proliferation of MV4-11 celineine.
In view of the above results, the aniline ring of 3 was replaced by 2,6-dimethyl aniline to increase the potency for LCK kinase.
We expect that confirmed hits from this screen may represent novel targets for therapeutically manipulating β-catenin/GSK3 signaling and potentially uncover strategies for combination therapies that may increase the potency of GSK3-specific inhibitors.
They also increase the potency of the allergenic proteins.
Epitope-based vaccines designed to induce cellular immune response and antibody responses specific for infectious bronchitis virus (IBV) are being developed as a means for increasing vaccine potency.
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CEO of Professional Science Editing for Scientists @ prosciediting.com