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Moreover, such compounds would have a potential to be used as pharmaceutical agents for increasing life span and promoting healthy aging by delaying the onset of age-related diseases, regardless of an organism's dietary regimen.
Calorie restriction (CR) is an effective and reproducible intervention for increasing life span, reducing oxidative damage, enhancing stress resistance and delaying/preventing aging and age-associated diseases such as cancer in various species, including mammals (mice, rats, and non- human primates) [ 5- 8].
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Clinical and pre-clinical studies have shown that females carry an increased risk of developing AD pathology compared to males, even after controlling for increased life span [ 40, 41].
However, higher levels of autophagy alone do not appear to be sufficient for increased life span, because daf-16 mutation blocks daf-2 longevity but does not reduce autophagy levels (Hansen et al., 2008).
-What are the potential advantages/disadvantages of increasing life span in humans?
Although environmental stress generally accelerates aging, it should be considered that exposure to a low level of stress or stress adaptation can actually be beneficial for the organism, increasing life span and preventing age-associated degenerative diseases [ 53- 56].
This view realizes that increasing life span can be a positive force for economic and social opportunity, enhanced cohesion and intergenerational harmony.
One reason for the pressure is increasing life spans.
Globally, populations are aging with increasing life spans.
Given increasing life spans, there is a genuine concern that even well-off people are at risk for outliving their money.
"To date, the data suggests that walking and light jogging are almost uniformly beneficial for health and do increase life span," Dr. O'Keefe says.
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