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The requirement for increased responsiveness has led to the development of new modular concepts which provide the bases for achieving higher system adaptability through increased component/module interchangeability and reusability.
Some have argued that increased involvement makes visible the 'patient work' (Corbin and Strauss 1985) and 'clinical labor' (Cooper and Waldby 2014) that sample donors provide in order for collections to become possible and operable, as well as allows for increased responsiveness to the interests and concerns of those who have participated.
Additionally, evidence for increased responsiveness to painful stimuli in FMS has been found by means of behavioural [15], [16], [17] and functional magnetic resonance imaging (fMRI) studies [11] indicating deficits in endogenous pain inhibitory systems which normally protect against overstimulation [18], [19].
In view of the wide effects of type I IFN on immune system function, including induction of macrophage differentiation toward a dendritic cell phenotype, increased immunoglobulin class switching and generalized priming of the immune system for increased responsiveness to subsequent stimuli, IFN-alpha represents a rational therapeutic target [ 35, 46].
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If we look at the second specification, the results are broadly similar to those obtained under the first specification with the exception of France where the evidence of increased responsiveness found for the whole private sector reflects developments in both industry and services.
For Italy, there is evidence of increased responsiveness of wage growth to the unemployment rate in both industry and services.
Interestingly, there are several lines of evidence to suggest that inhibition in the auditory cortex could actually be responsible for an increased responsiveness to auditory stimuli.
Functional studies have tried to establish which of the two missense variants is causal: in recent elegant work, Hamming and colleagues [ 35] have demonstrated that the A allele at Ala1369Ser is responsible for the increased responsiveness to gliclazide shown by mutated channels in vitro.
Thus, the mechanism for leptin increased responsiveness in exercise is of great interest and understanding this mechanism could lead to new approaches to prevent or treat obesity.
Predictably, loss of PRDX4 could lead to a reduction of phosphatase activity, providing an explanation for the increased responsiveness of APL clonogenic precursors to G-CSF.
Finally, we assessed cellular signaling mechanisms that might account for the increased responsiveness of Hif-1α mutant mice to PTH.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com