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Basic amine analogues were found to be important for increased potency.
The evidence for increased potency of drug rewards varies substantially across different neuroscience methods.
Greater utility may be achieved via molecular targeting for increased potency (discussed later).
Multivalency effects provided for increased potency compared to the monovalent ligands in both the GalA and the GalB series, as indicated by the ratio K d GalAG0/ K d GalAG2=42 and K d GalBG0/ K d GalBG2=129.
10 This allows the dose to affect the binding of memantine without affecting its removal from the site of action and allowing for increased potency with minimal side affects.
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A possible reason for this increased potency is the tendency for cells to compensate homeostatically for a significant change in the expression of a single gene.
The bicyclic amine is mainly responsible for the increased potency of the substance, while the cyano-group is responsible for its enhanced activity against first- and second-step fluoroquinolone resistant bacteria [ 1].
As with most other illicit drugs, prohibition is also to blame for the increased potency and addictiveness of meth today.
Marinolic acid inhibited S. aureus (MIC = 1 µg ml−1) but less well than mupirocin (MIC = 0.125 µg ml−1) confirming that the added pyrrothine is responsible for the increased potency of thiomarinol.
In vitro tests of these new TKIs show considerably higher activity in comparison with imatinib, with a 40-fold increased potency for nilotinib and a 325-fold for dasatinib [ 3].
Gandotinib (LY2784544), a potent inhibitor of JAK2 activity, shows increased potency for the JAK2V617F mutation.
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