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Even though our sample size was limited and final 24-month treatment outcomes are needed to definitively demonstrate the effectiveness of this strategy, our high rates of culture conversion and lower mortality rate pave the way for improved cure rates in MDR-TB and HIV co-infection, even in rural, resource-limited settings.
This improvement is a necessary first step in the move towards dose escalation, with the potential for improved cure rates.
Therefore, hope for improved cure of lung cancer patients was based on approaches to detect small and usually asymptomatic early stages non-small cell lung cancer using diagnostic tests.
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Because there is widespread misunderstanding of the nature of clinical trials and the enormous potential they offer for improving cure rates and long-term survival.
Recently, the emergence of intensity-modulated RT [ 3] and molecular-targeted therapy [ 4] has provided hope for improving cure rate.
If true for neuroblastoma, improved cure rates may only be achieved via identification and therapeutic targeting of the neuroblastoma tumor initiating cell.
Key points Accurate GTV delineation is the key to improved cure rates for NSCLC and a prerequisite of sophisticated radiotherapy delivery using CFRT and IMRT.
The key to improved cure rates for non-small cell lung cancer lies in accurate target volume definition without which sophisticated conformal radiotherapy will be delivered as a geographical miss.
Chemotherapy for muscle invasive TCC improves cure rates in combination with radical treatment options (Grossman et al, 2003; Advanced Bladder Cancer ABCC) Meta-analysis Collaboration, 2005a, 2005b; International Collaboration of Trialists et al, 2011) and extends survival in metastatic disease (von der Maase et al, 2000, 2005).
In theory, combination treatment thus should improve cure rates for deep infections such as S. aureus mastitis [ 24].
This intense supervision however did not improve cure rates (53% for home observation and 49% for clinic observation; RR 1.01, 95% CI 0.91 to 1.11; four trials, 1556 participants, Analysis 2.3).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com