The goal of this study was to determine whether these treatment-induced changes in tumor hypoxia can be detected and quantified using a PET radiotracer for hypoxia in an animal model.
As we have discussed in this review, hypoxia-induced ER stress can lead to alterations in glycosylation patterns, suggesting a potential role for hypoxia in mucin response to infections and their role in pathogen clearance.
Cells were cultured at 5% CO2, 21% O2 for normoxia and 1% O2 for hypoxia in an Invivo2 Hypoxia Workstation 1000 (Biotrace International, UK) at 37°C.
Its hypoxia-dependent expression in neuroblastoma may reflect an important role for hypoxia in the normal development and stress-adaptation of the fetus.
Although autophagy is best known for its role in generating amino acids and energy required for cell survival during periods of nutrient deprivation and hypoxia, it has also been implicated as a pathway for the elimination of aberrant proteins.
The mouse model of oxygen induced retinopathy (OIR) was selected as a mouse model for hypoxia and generated as published.
Effectiveness in generating knowledge for ECD.
Other recent studies reveal that KATP channels not only have an essential physiological role in generating vasomotor responses, but their activation substantially boosts the lethality of hypoxia.
In particular, noise causes cochlear hypoxia by generating edema in the stria vascularis with breach of the blood-labyrinth barrier [49], while the molecular mechanism for noise induced disruption of the barrier is not fully understood.
In disease, tissue hypoxia is generated in a complex tissue environment, with wide variation in the local levels of oxygen because of differences in oxygen supply and consumption.
