Deficits in energy metabolism and autonomic function in ALS suggest the possibility of hypothalamic dysfunction, which may be indicated by pathologic TDP-43 deposition.
Many of the hallmark symptoms of depression reflect processes indicative of hypothalamic dysfunction, such as disturbances of mood, appetite, sleep, sex drive, and motivation.
This is likely another key reason -- along with the hypothalamic dysfunction, gland dysfunction and receptor resistance -- for the widespread hormonal disorders we see in CFS/FMS.
Limbic dysfunction, in addition to hypothalamic dysfunction, might also be a possible reason for headaches in adolescents with eating disorders [ 33], where abnormal levels of several neurotransmitters (e.g., dopamine) are present.
A hypothalamic dysfunction can be hypothesized as a link between both conditions.
The present review examines OSAS and hypothalamic dysfunction and other contributing factors to EDS in PWS.
Current hypotheses are focused on vasomotor changes, inflammation, immune changes, autonomic system imbalance and hypothalamic dysfunction [3].
Objective: Hyperphagia in Prader-Willi syndrome (PWS) is hypothesized to be due to hypothalamic dysfunction; thus the study of individuals with PWS might illustrate how hypothalamic dysfunction affects eating behavior.
Problems with body temperature regulation have been reported in ONH, presumably due to hypothalamic dysfunction, with these patients sometimes requiring hospitalizations to rule out infections [16].
We felt the pituitary cyst was most likely an incidental finding and not the likely cause of her mild hypothalamic dysfunction and SUNCT headaches.
