Mr. Marceau, who could be voluble in interviews, once said of his pantomime: "Mostly I think of human situations for my work, not local mannerisms.
Therefore, patient survival data are the only source for parameterising models for the human situation.
For if my heart swells as I watch son part from mother, or lovers lose their chance of happiness, it swells not only for the characters but for the human situation to which the performance gives me access: I weep that sons must part from mothers, that things should be so".
Consequently, such an experiment would be uninformative for the human situation and provide no evidence for a therapeutic window for CG in cancer therapy.
For the predictive value of preclinical animal models for the human situation, it is important to realize that major differences exist in nasal features between conditions, such as species differences, especially between animals and humans (9, 19, 20).
Furthermore, in vivo mammalian tests are unsuitable for screening large numbers of agents, and their predictive capacity for the human situation remains unclear.
Where his earlier work had relied on ingeniously wrought metaphors and parables for the human situation, the later anti-fictions largely give up on this fictional effort in favour of informal, cracker-barrel philosophising from the author himself.
In this review, all known animal models of HLH will be discussed, highlighting findings on cell types, cytokines and signaling pathways involved in disease pathogenesis and extrapolating therapeutic implications for the human situation.
Admittedly it is by no means certain that the xenograft model used in this study is fully predictable for the human situation, but our results show at least the expediency of viral immunoevasins in hMSCs and provide a rationale for transferring additional immunoevasin genes to generate universal donor cells.
In fact, the same is true for the human situation.
