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The median mRNA expression levels and RpII18 binding levels both exhibit a sharp transition at LAD borders (red lines in Fig. 1e and 1f), similar to what has been reported for human LADs [8].
As is the case for human LADs, almost all genes inside LADs are expressed at baseline levels, while genes outside LADs display varying and on average higher expression levels (Fig. 1e).
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Even though Drosophila LADs are about five-fold smaller than human LADs, the number of genes per LAD is remarkably similar between the two species.
Human-specific LADs constitute more than 21% of all LADs in the human genome, indicating that genome-wide interaction profiles with nuclear lamina and three-dimensional folding patterns of human chromosomes are markedly distinct.
The average length of human-specific LADs is 361 kb, which is 2.7-fold shorter than the average length of all LADs in the human genome (980 kb; P = 5.382 E-62), and 25 40% of all LADs of nearly half of all human chromosomes are represented by the human-specific LADs (fig. 2 and supplementary fig. S3, Supplementary Material online).
So got for it, lads!
I'm delighted, delighted for the lads.
One for the lads, or lavs?
Decent training kits for the lads, decent hotels for the lads and decent travel arrangements for the lads.
Save something for Sunday lads.
"I'm delighted for the lads.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com