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For highly selected traits, realized accuracy of GEBV is smaller because it accounts for selection.
If ED physicians are very selective for ICU candidates, this will result in ICU admission requests for highly selected patients only, then a low refusal rate by intensive care physicians.
However, this procedure is usually applied for highly selected patients.
This may mean that there should only be an attempt to spare the neurovascular bundles for highly selected cases.
Doko et al agreed that the one-stage procedure should be reserved only for highly selected patients with absolute indications.
High-dose interleukin-2 remains an option for highly selected patients and is associated with durable remission in a small minority of patients [ 6, 7].
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EPP, the en bloc resection of the pleura and lung, is typically reserved for a group of highly selected medically fit patients with lower volume, epithelioid MPM.
A pleuropneumonectomy would seem to be warranted for a small number of highly selected patients with advanced or recurrent thymoma extensively involving the pleural space.
For a tiny minority of highly selected young patients who are already dependent on inotropes or mechanical circulatory support, cardiac transplantation is an invaluable solution.
In our programme a tiered approach to biopsy is applied, using a combination of FNAB and core biopsy with referral of highly selected cases for surgical excision.
Current estimates of the penetrance of known risk mutations are based on ascertainment from highly selected populations (for example, patients with developmental disorders) who may have a higher burden of other mutations than is representative in the general population.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com