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The classifier threshold was specifically tuned to for higher specificity at the expense of sensitivity in order to provide high confidence identification of non-responders (see Methods).> -wrap-foot> Patients with classifier scores above 5.96 are predicted non-responders and thus potential candidates for alternative biologic therapy.
In contrast to most small-molecule kinase inhibitors, the AR proteins are not restricted to active site binding, allowing for higher specificity.
When all spots are analyzed together, the mix control is responsible for higher specificity, without loss of sensitivity.
On the other hand, investigators aiming for higher specificity only used claims indicating radiation delivery in the form of EBRT [ 17], sometimes with radiopharmaceuticals [ 14].
The performance of MLR and CRT models was similar, except for higher specificity of the CRT at 72 h, compared to MLR analysis.
MuTect, with its default setting under HC mode (high-confidence mode), achieved lower sensitivity than Strelka (about 0.60), although this might in part be due to MuTect being tuned for higher specificity.
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Eisenhardt, S. U., Schwarz, M., Bassler, N. & Peter, K. Subtractive single-chain antibody (scFv) phage-display: tailoring phage-display for high specificity against function-specific conformations of cell membrane molecules.
Thus, our probe design provides a means of synthesis quality control, possesses a short CDR3β-specific region for high specificity, yet is of sufficient length to generate robust hybridization signals.
AMS traces low‐abundance radioisotopes for high specificity but detects them with MS for high sensitivity.
Nevertheless, distinct differences in the receptor binding sites allow for high specificity between ligands.
The need for high specificity lies in choosing the optimal parameter to be measured and monitored.
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