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Supporting these results, we also detected trends for higher responses with the 0.5-μg dose in the AS01E group for DENV-2 and DENV-3 (geometric mean ratio [GMR] > 2; P < 0.10).
The need to compare highly effective targeted agents to standard of care chemotherapy, the lack of biomarker testing in the community setting, tissue availability, and the ability to receive optimal pricing for higher responses in a smaller population are but a few of the challenges.
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Quadratic effects were not considered since their inclusion led to unrealistic model behaviour for higher response values which we interpreted as a result of overfitting the model.
This could be an important advancement in the therapeutic options of oncologic patients, allowing for more targeted and personalized chemotherapy regimens as well as for higher response rates.
A trend for higher response rates with lonidamine-containing regimens was also observed, though statistically significant differences in response rate, median TTP, and OS were observed only in the trial of cisplatin epirubicin and vindesine with or without lonidamine (Table 4).
One of the plausible explanations for higher response rate achieved with pazopanib would be high number of patients with colorectal NETs, with only one-third of the enrolled patients suffering from pancreatic NET (n=12) (Raymond et al, 2011; Yao et al, 2011b).
In addition, because this valve uses the PZT transducer, the valve has potential for high response.
Specifically, field annealing as well as magnetic domain engineering is described for high response signals.
The optimum temperature for highest response magnitude and lowest response time were found to be 250 °C although relatively high (76.6%) response is obtained even at as low as 150 °C.
A crucial requirement for high response rates is accurate contact details.
Investigators continue to research other targeted therapies for high response rates, less toxicity, and less need for chronic glucocorticoid treatment.
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