A reasonable explanation for the high lifetime prevalence and incidence in this study is related to the response options of the first question ("Have you ever had neck pain?") which were "often"/"sometimes"/ once or twice"/ never".
What is more, the URL scheme can be easily adopted by vary network coding based data collection scheme and provides an easily implementable solution for reliable and high lifetime data collection in WSNs.
However, bowel cancer is an ideal disease for screening, with high lifetime incidence and prevalence in the screening age range [ 10], and being severe, detectable and curable with low morbidity at early stages of disease.
A number of genes have been identified during the past 10 years which, when inherited in a mutant form, confer a high lifetime risk for breast cancer and for a spectrum of other cancers.
Although more than three-fourths of the study population are at low (<10%) short-term predicted risk for a CHD event, nearly half are at high lifetime predicted risk for CVD based on their current aggregate risk factor burden.
However, it may not identify subjects with low short-term but high lifetime risk for CHD, likely due to changes in risk factor status over time.
BRCA1 and BRCA2 are major susceptibility genes that confer high lifetime risks for both breast and ovarian cancer.
Women with a BRCA1/2 mutation have a high lifetime risk for breast cancer (56 85%) and/or ovarian cancer (16 63%) (Easton et al, 1995; Struewing et al, 1997).
Germline mutations in BRCA1 and BRCA2 confer a high lifetime risk for breast and/or ovarian cancer, and early studies of familial cancer cases suggested that these risks may be as high as 80% [ 10, 11].
Accordingly, instead of using the term monogenic obesity, we consider it more appropriate to think of MC4R mutations as resulting in strong effect sizes conveying a high lifetime risk for obesity.
