Sentence examples for for heart development from inspiring English sources

Are genes the primary supplier and organizer of material resources for heart development, largely determining the phenotypic outcome?

Mef2c is required for heart development [35].

We designed Nkx2.5- and Nkx2.7-MO to study whether Nkx2.5 or Nkx2.7 is required for heart development of zebrafish.

In addition, we have previously shown [40] that signaling of TGFbeta family members in the endoderm is required for heart development.

Both Hand1 and Hand2 are essential for heart development as either germ-line or cardiac-specific deletion of Hand1 and Hand2 in mice causes heart defects and mortality [5], [8], [14], [15].

The non-canonical and canonical Wnt signaling pathways are indispensible for heart development [4], [5] and other biological processes including cell migration, cell proliferation, development [6], [7], and stem cell self-renewal [8], [9].

With defined culture protocol, human embryonic stem cells (hESCs) are able to generate cardiomyocytes in vitro, therefore providing a great model for human heart development, and holding great potential for cardiac disease therapies.

Our study shows that Tie-1 and Tie-2 are not required for early heart development, yet they have redundant roles for the maintenance of endocardial-myocardial connection in later stages.

Together, all these studies demonstrate that appropriate YAP activity is crucial for embryonic heart development and basal heart homeostasis, and YAP could stimulate cardiomyocyte proliferation and cardiac regeneration in response to heart injury such as myocardial ischemia.

RCAN1.4 negatively regulates NFAT-mediated transcription (Lange and Yutzey, 2006; Qin et al., 2006), which is an important regulator for early heart development (de la Pompa et al., 1998).

Using two Nkx2.5- and Nkx2.7-specific MOs, we demonstrated that Nkx2.5 and Nkx2.7 are required for normal heart development.