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For global alignment, we use a graph-based approach making use of the same error metric and iteratively refine the complete vehicle trajectory.
ClustalW [61] tool was used for global alignment of single HGT candidates with their best bacterial hits.
The affine transformation is commonly used for global alignment.
The best hits were retrieved for global alignment with ClustalW2 [ 29].
G(T) is the similarity function for global alignment of region T for DNA sequences from QT set.
The simplicity and generality of GraphAlignment edge scoring makes the algorithm an appropriate choice for global alignment of networks.
Similar(40)
The aforementioned procedure is known as the Needleman Wunsch algorithm [ 29] and is appropriate for global alignments (i.e. when both sequences are to be aligned in their entirety, such as when comparing two complete genes: see Figure 10A).
These non-informative sequences clearly outweigh the informative ones, and so they obscure the information and make the scores for global alignments less useful.
Multi-sequence alignments were made using MAFFT software (http://align.bmr.kyushu-u.ac.jp/mafft/software/) with the "G-INS-I" setting for global alignments, corrected manually.
This is indicated by the 'deRIP improvement' factor and the differences in percent identities for global alignments.
Recurrence (2) is the obvious modification of the recurrence presented in (Jiang et al., 1995) for global alignments and node similarities.
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