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Our results reveal that PCNA unloading by Elg1-RLC is critical for genome maintenance.
In budding yeast, the production of histones in the correct stoichiometry is important for genome maintenance and successful cell cycle progression [2], [9], [10], [11].
Elg1 is therefore crucial for genome maintenance.
Many mechanisms for genome maintenance are conserved between yeast and humans (Taylor and Lehmann 1998).
Our results provide broad insights into the cellular processes and pathways required for genome maintenance.
There is an increasing knowledge on molecular mechanisms that are important for genome maintenance in adult tissue stem cells.
Similar(39)
Instead, the ubiquitin ligase domain is required for Rad8 to promote genome stability in response to a variety of stresses, suggesting that PCNA modification is required for multiple facets of genome maintenance.
EBNA1 is essential for viral genome maintenance and for infected-cell survival [6], [7].
Understanding how these activities cooperate and compensation for each other will continue to provide valuable insights for understanding genome maintenance.
EBNA1 is an EBV-encoded DNA-binding protein required for viral genome maintenance during latent infection.
Epl4 functions as an elongator complex subunit required for modification of wobble nucleosides in tRNA; Sps1 is required for localization of enzymes involved in spore wall synthesis; and Rim1 is a single-stranded DNA-binding protein essential for mitochondrial genome maintenance.
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