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trans-Stilbenes thus represent attractive scaffolds for future compound development.
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Compound 11 therefore represents a suitable lead compound for future drug development projects, due to its novel conformationally constrained structure, its "lead-like" properties and desirable affinity, efficacy and selectivity characteristics.
Altogether, we concluded that SA1 and SA2 might be potential antidiabetic lead compounds for future drug development.
Results from this study provided a potential lead compound for future CCR5 antagonist development focusing on prostate cancer therapy.
This strong activity rivals currently used commercial fungicides, such as Boscalid and Carbendazim, and has great potential as a lead compound for future development of novel fungicides.
Two compounds were highly potent against the HL60 cell line and represent promising lead compounds for future development.
These results provide a basis for future development of these compounds as anti-cancer and anti-inflammatory agents.
From this correlation an optimum RM value, close to 1.44, was found, which may be used as design guide for future development of antitrypanosomal compounds.
In summary, compounds 1 and 2 identified in the present study exerted cytotoxicity against breast cancer cells, providing a basis for future development of these compounds as novel anticancer agents.
In this context, recent studies in our laboratory have shown that certain QSI scaffolds can evade active efflux in P. aeruginosa via the MexAB-OprM pump, which serves to leverage these compounds for future development.
Given the low toxicity of most chemical chaperones tested, these compounds might be good candidates for future drug development.
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CEO of Professional Science Editing for Scientists @ prosciediting.com