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Such results need to be interpreted carefully and emphasize the need for further well designed studies to characterize the actual influence of the Hh pathway in CRC prognosis.
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There is a need for further well-designed and adequately powered randomized controlled trials.
There is thus a need for further well-designed, double-blind, controlled trials investigating the effectiveness of other preventive treatments, and prolonged, longer follow-up periods.
Therefore, there are significant opportunities for further well-designed epidemiological studies on a larger scale than currently reported in the majority of the Arab nations.
There is a need for further well-designed studies to identify the elderly patients who will benefit most from prophylactic G-CSF.
Finally, there is a need for further well-designed, longitudinal, survival studies to clarify the relationship better between depression and the different stages of renal dysfunction.
There is an urgent need for further well-designed multicentre trials of existing and novel therapies that may alter the natural history of the disease.
Clearly, there is a need for further well-designed studies addressing this issue.
However the evidence remains inconclusive, indicating the need for further well-designed research.
Therefore, we conclude that there is a need for further well-designed studies to evaluate the effect of patellar bracing on pain in PFPS.
Although several of these novel biomarkers have an improved predictive accuracy that is better than classical parameters, there is still a need for further well-designed, large, multicenter, prospective trials to avoid common bias and clinical validation.
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