Exact(7)
Therefore the top twenty hot spot grids were identified for further profiling.
Potency, selectivity, and pharmacokinetic properties were optimized resulting in the identification of a pre-clinical candidate for further profiling.
It was found that replacement of the northern appendage in 1 with an N-methyl pyridone and subsequent re-optimization of the benzyl amide handle afforded compounds with in vitro and in vivo profiles suitable for further profiling.
Based on the results of the efficacy studies in the hamster and dog models of dyslipidemia and the desired pharmacokinetic data, the optimized compound 39 was selected for further profiling.
This compound was assumed to be least sensitive for different dosing approaches and was selected for further profiling.
Therefore we defined these sequence variants as conserved miRNAs and focused on the miRNA/variant sequences with >300 reads for further profiling analyses (Additional file 3: Table S3).
Similar(53)
Therefore this procedure was used for all further profiling experiments.
These 12 genes were selected for further expression profiling in a larger series of melanocytic tumour lesions.
About twenty ESTs spanning different functional groups were used for further transcript profiling analysis in our system during the later stages of mycorrhiza development.
Therefore, this strategy may allow enrichment of CTCs for further CTC profiling and downstream analysis and may also be beneficial for the isolation and detection of CTC clusters), which is another advantage in the clinical application [ 23, 24].
In wild type, ERα-/ and ERβ-/ mice, a similar level of TT-specific swelling was observed in vehicle-treated mice, which allowed for further compound profiling in this model.
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