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Although the parents' ethnicity and the gender of previous children capture some heterogeneity among households, they do not allow for further heterogeneity among the subgroups.
We observed that inferred clusters mapped to intrinsic subtypes, as well as providing evidence for further heterogeneity within subtypes, confirming similar results reported in [ 14].
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The inclusion of further heterogeneity for the example of Fig. 9 did not improve the fitting, though other model choices may of course perform better.
A systematic mutation screening in 140 index cases with periodic catatonia and five cases with MLC detected a high degree of sequence diversity of MLC1 with evidence for further allelic heterogeneity of MLC1 mutations in MLC, but unfortunately the study failed to validate an association of schizophrenia to genetic variants of MLC1.
Given that these genes only account for about the half of all NPH cases, further heterogeneity can be expected.
Further, heterogeneity is likely to emerge as a critical marker for resistance to chemotherapy (Lee and Swanton 2012).
may cause further heterogeneity (Beck et al., 2013b).
Poisson regression allowed for further adjustment for heterogeneity across studies.
Using the DOR for further investigation of heterogeneity means that we can only assess whether the factors investigated are associated with the DOR and not with sensitivity and specificity, or with positive and negative likelihood ratios.
While the medications for such a clinical trial are already available, the lack of clear diagnostic criteria for EOAD subtypes hampers implementation, further underscoring the urgent need for further research in AD heterogeneity.
The extra parameter from the stretched exponential model provides scope for further investigation of inter-lesion heterogeneity or response to treatment.
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