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This review aims to highlight candidates with potential for further clinical development based on their putative modes of action.
The characteristics of compstatin suggest that this peptide and its analogs could be attractive candidates for further clinical development.
Furthermore they inhibit both early and late steps of the replication cycle which increases their potential for further clinical development.
We conclude that GMZ2 is a safe and immunogenic malaria vaccine candidate suitable for further clinical development.
These findings have implications for further clinical development of JX-594 and other transgene-armed oncolytic viruses.
JNJ-38893777 was recently shown in a human study to be well tolerated without causing serious adverse events and to be suitable for further clinical development [60].
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The efficacy and design of this immunotherapeutic approach render the strategy very attractive for further clinical developments.
In vitro pharmacokinetic studies have suggested that CA-1-P is transformed into a more reactive metabolite than CA-4-P, which is responsible for most of the antitumoral activity; this has formed the basis for further clinical developments of the drug as an antivascular and antitumor agent [ 77].
There are currently no efforts for a further clinical development of NOX-C89 or its follow-up candidate NOX-L41, but this might become more attractive in case the anti-CGRP antibodies are effective but need to be abandoned for unforeseen reasons.
In 2003, Zealand Pharma outlicensed lixisenatide to Sanofi-Aventis who is now responsible for all further clinical development.
CHMI data inform the decision for or against further clinical development of candidate vaccines, including whether to test in a pediatric population.
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CEO of Professional Science Editing for Scientists @ prosciediting.com