However, this prodomain binds directly to LARGE, an event that is a prerequisite for functional modification of the mucin-like domain of α-dystroglycan (Kanagawa et al. 2004).
Furthermore, the deterioration in performance and the differences noted in AD and DLB patients may be due to the different speed at which the process of the protein degradation occurs for functional modification of synapses.
In earlier studies, the peptide scaffolds of triostin A, des- N-tetramethyltriostin A (2, TANDEM) (Ciardelli and Olsen 1977), and the peptide analog aza-TANDEM (3) (Dietrich and Diederichsen 2005) were used as rigid templates for functional modification in order to generate a new class of DNA binders (Fig. 1).
This data will serve as a tool for validation and the potential addition of functional modification sites in Reactome.
Thus, the targeting of laminin-binding integrins to TEMs by CD151 creates many opportunities for functional collaborations between the integrins and other cell-surface proteins, or for the functional modification of integrin-mediated responses.
A sizing technique has been used for localized functional modification using CNTs.
Splice variants possessing the exon-5-encoded motif at the amino-terminal domain (ATD) of the GluN1 subunit are known to display robustly altered deactivation rates and pH sensitivity, but the underlying mechanism for this functional modification is largely unknown.
This review surveys the most recent developments in low frequency, high power ultrasound for the functional modification of proteins derived from a number of food sources (e.g. dairy, animal, cereal, legume, tuber and fruit), and subsequently for the fabrication of nano-sized emulsion droplets.
Our results suggest that LARGE and LARGE2 catalyze the same glycosylation reactions for the functional modification of α-DG, but that they have different biochemical properties.
This indicates that TGFBR1*6A makes for some functional modification of TGF-β signaling which stimulates the occurrence of osteosarcoma without regard to gender, age and location.
