Sentence examples for for functional effects from inspiring English sources

This approach combined with bioinformatics, including software to interrogate polymorphisms for functional effects provide an effective method for discovering the genes behind multigenic diseases such as cancer.

The evaluation module produces predictions for functional effects of SNP to protein function for non-synonymous coding SNPs, using four prediction tools: PolyPhen [11], PolyPhen-2 [12], SNPs3D [13] and SIFT [14].

"Topiramate hits quite a lot of targets and has complex side effects, while the doses needed for functional effects for cimetidine seemed high," he cautions.

At the end of the studies, mice were tested for functional effects in the water maze.

First evidence for functional effects of ANP on EDS cells was obtained in current clamp experiments.

However, that study did not test for functional effects directly related to maternally injected cytokines.

However, since there was little evidence for functional effect for the SNPs analysed, based on bioinformatics analysis, the prior probability of 0.01 was also taken into consideration.

However, we previously established that relationships to disease provide much stronger evidence for functional effect of variants than any other experimental evidence [ 17].

SIFT, PolyPhen-2, and MutationTaster were used for prediction of functional effects of the selected variants.

The final step before association analysis is annotation of functional effects for each variant.

Resources for inferring functional effects for "-omics" big data are largely based on statistical associations between observed gene expression changes and predicted functional effects.