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However, the current proposals for the development of the early stages of software do not provide an effective means for functional changes and updates.
The lab is currently evaluation the fish for functional changes in the heart such as valvulopathy (diseases of the heart valves), hemorrhage (bleeding), hypertrophy (swelling), and others.
APS and HPS haplotypes associated with pain sensitivity code for functional changes in COMT.
During T cell stimulation, expression of CD44 variants (v3, v6, v9) may be necessary for functional changes post-stimulation [43], [44].
Further investigation of these genes may shed light on how the parasite compensates for functional changes accompanying drug resistance mutations in a gene coding for a membrane/drug transporter.
The major open question regarding the evolution of the vertebrate inhibin/activin gene family are when the duplication that led to the α-subunit occurred and what the implications of that timing were for functional changes that led to the origin of inhibin.
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While SNAP operates on an experimentally substantiated definition of change, SIFT uses conservation scores of amino acids as a proxy for functional change.
For functional change, using the SEADL as the most sensitive scale, we would have been able to detect differences in annual rate of progression of 32% for PSP and 36% for MSA.
Inference of syntenic homologs provides the basis for correlation of functional changes around genes of interests between related organisms.
Furthermore, serial scanning can be performed, which allows for measurement of functional changes over time during therapeutic interventions.
This paper describes the approach taken and the results to develop guidance, to include Resilience Engineering principles in methodology for safety assessment of functional changes, in Air Traffic Management (ATM).
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