Suggestions(1)
Exact(2)
Purified HRP-SpG was tested successfully for functional binding of antibodies from different mammalian serums.
The lack of significant enrichment among the predicted primary Ahr responders suggests that our knowledge of the sequence-level requirements for functional binding of Ahr is currently far from complete.
Similar(58)
The muteins K126A, K126E and E257A where completely inactive, demonstrating the importance of these residues for the functional binding of the substrate.
This suggests that our approach is giving some reasonable estimate of the energetics of Met4 binding, with a clearly defined threshold for functional binding sites.
However, ChIP data alone is insufficient for identifying functional binding target genes of TFs for two reasons.
However, ChIP data alone are insufficient for identifying functional binding target genes of TFs for two reasons.
Among the non-functional binding sites in Figure 1, there is an almost constant acetylation level across all histone lysines, which may be either high or low; for the functional binding sites, however, the equilibrium of the histone acetylation levels on the different lysines is broken, which results in a TF-specific perturbation of acetylation levels.
To obtain genetic evidence for negamycin's functional binding site, helix 34 of the small subunit, the redundancy of wild-type E. coli ultimately needed to be circumvented by the use of markerless single rrn strains (Olivier et al. 2014; Polikanov et al. 2014a).
A critical molecular mechanism to ensure this robustness is selection for clusters of functional binding sites (Berman et al. 2002; Berman et al. 2004), as evidenced by the evolutionary conservation of TFBSs at enhancers in the BX-C (Ho et al. 2009; Starr et al. 2011) and at the even-skipped gene (Crocker and Erives 2008; Hare et al. 2008b; Ludwig et al. 1998) in divergent insect species.
The method, combined with binding sequence and location conservation between human and mouse, identifies with high probability functional binding sites for groups of functionally-related genes.
We isolate and test the sea star otxβ1/2 cis-regulatory module and demonstrate functional binding sites for each of the predicted inputs, including Tbrain.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com