M-53 turns northeasterly, running as an expressway, with at-grade intersections for access at the key cross roads instead of full interchanges.
On the north side of Grayling, there is a full interchange for BL I-75/M-93 I-75/M-93 I-75/M-93outhatund I-75 connection to M-72 as well as access from both directions to the Hartwick providesathePark.
Between when IL 98 was opened and when the corner was closed in 1989 for construction of a full interchange, 15 people were killed as a result of automobile accidents at the corner.
On November 21 , 2008 construction began on making the interchange with the Atlantic City Expressway a full interchange as part of a series of improvements set for the Atlantic City Expressway.
The Maugansville Road interchange was originally a full interchange, but was reduced to a partial interchange in 1968.
Past this interchange, Route 50 widens to a four-lane divided highway and reaches a full interchange with the Atlantic City Expressway.
Past CR 689, there is a full interchange with County Route 536 Spur.
Continuing to the southeast, it encounters Route 54 at a full interchange.
However, after a full interchange with US-77, the road becomes a two lane highway again.
In Enfield, the road becomes known as King Street, crossing over I-91 with a full interchange (Exit 46).
