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At 3- and 6-month follow-up, the children were evaluated for full function, minor limitation of function and major loss of function.
Each of utrophin's actin-binding domains promotes resilience in actin, while dystrophin constructs require the presence of both actin-binding domains and the C-terminal domain for full function.
The good news for Wicket and many with mitral prolapse is that the source of all the noise is not a problem for full function.
Thus, the N-terminal part of Dmknδ5 is necessary but not sufficient for full function on Rab5 activation.
Notably, heterozygous mice did not show any abnormalities in postnatal growth and survival as well as blood or bone parameters highlighting that only one Wwox allele is sufficient for full function.
Secondly, since MODY is known to be a disorder of haploinsufficiency [13], [14], we cannot rule out the possibility that there may also be species-specific differences in the dosage of the HNF1A, HNF1B and HNF4A gene products that are required for full function.
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It is also possible that large genomic deletions disturb the communication between the homologous alleles required for their full function by deleting regulatory elements required for this process [ 26].
All selected amino acids (H93, H116, H125, F273, C97, H252, H256, H286) are essential for the full function of the enzyme and therefore essential for substrate binding.
Alternatively, CaZF can partially complement salt sensitivity of the can mutants but requires the CAN pathway for its full function.
Here, we provide evidence that the putative CUE motif of the budding yeast Fun30 is required for the full function of the protein.
Therefore, we speculated that the two genes might be required for the full function of this locus.
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