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Thus, region-specific administration may be necessary for full efficacy, and this constitutes a major hurdle for noninvasive peripheral administration.
A study in Uganda has shown the benefit of training TBAs to refer cases of obstructed labour and fistulas but the authors note that for full efficacy of the TBA intervention, training must be accompanied by greater collaboration between health workers and TBAs [ 40].
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Success for the existing AUD treatments is only moderate and likely limited by poor compliance, toxicity, individual variation, and possibly lack of full efficacy.
SAR studies indicated that electron-withdrawing substituents on the phenyl ring are important for potency and full efficacy.
Analogue 2 has slightly less affinity than 1, but shows full efficacy for the D1 receptor.
While nanoparticles without added sucrose rapidly lost efficacy, nanoparticles formulated at 30 and 45 mg/mL sucrose maintained full efficacy for at least 2 years when stored at −20 °C.
This has been demonstrated with the OROS preparation of MPH, which provides an initial low-dose MPH bolus and an ascending MPH delivery profile across the day, and maintains full efficacy for 12 h with once-daily oral administration [ 99].
While Caucasian men present with 60 70% suppression to azoospermia, the prerequisite for full contraceptive efficacy, reports from China have shown contraceptive efficacy rates of >90% (15, 16).
However, many of the most promising protein therapeutics require post-translational modifications such as glycosylation for full therapeutic efficacy.
Recent data indicate that full efficacy of a hand rub preparation for hygienic hand disinfection can be achieved within 15 seconds (s).
Full efficacy data are awaited with interest.
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