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We did not include fixed combination products in our analysis, because the DDD assignment for fixed combinations differs from that for single ingredient products.
Inhalers for fixed combinations of ICS and LABA include pMDIs and DPIs.
Furthermore, it could be shown for fixed combinations of travoprost and timolol, and bimatoprost and timolol, that evening dosing provided a better 24-h IOP control when compared to morning dosing [ 38, 39].
The DDD for fixed combinations, such as ACEIs or ARBs with diuretics, do not depend on the dose rate of the single ingredients, but are based on the average number of dosing intervals per day.
For fixed combinations of n and m, the phase φ mat was determined for each fetal R peak (index i), the absolute difference δ i = |φ mat, i - φ mat, i + n | was calculated and a sliding window of length l was moved over all δ i. If, within the window, all δ i < threshold value α, an SE was considered detected (e.g. in Fig. 6, black points in bottom panel).
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In NL, off-label use was observed for the fixed combinations of ß2-mimetics + anticholinergics.
For the fixed combinations of ICS + LABA, use was highest in NL with six per 100 PY in children with asthma.
Adverse events for this category were counted only once for each patient Fixed combinations of PGAs and timolol are widely used in glaucoma management because they offer several advantages; most of all, the use of one bottle compared to the concomitant use of the individual components increases patient convenience.
Most trials of homeopathy have not studied classical homeopathy that individualises treatments for patients, but used either fixed combinations for certain symptom clusters, or isopathy, i.e. the same substance that triggers an allergic response, or simplified versions of homeopathy.
In comparison, prescriptions of fixed salmeterol/fluticasone combination for Italian asthma patients increased between 2006 and 2008 by 45% whereas for formoterol-containing fixed combinations, a much more pronounced increase by 137% was found [ 19].
Thus, PF prostaglandin/timolol FC for the treatment of patients with glaucoma and ocular hypertension may have potential benefits for patients using fixed combinations of a prostaglandin analog and timolol.
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