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However, there are several disadvantages to the use of ZFNs, including their expense and the need for extensive screening in order to optimize binding specificity for each target sequence of interest (reviewed by Davis and Stokoe, 2010).
The results from this study indicate G. edulis exhibited antiproliferative and apoptotic activities against EAT cells in vitro and is a promising candidate for extensive screening in animal model.
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These results reinforce the importance of extensive screening for HIV infection, earlier initiation of antiretroviral therapy and stricter monitoring of pregnant women to reduce the risk of detectable HIV RNA at delivery.
The possible evolution towards further deterioration of renal function in patients with renal artery stenosis and the results of relatively non-invasive renal stenting procedures for prevention and treatment, are indication for an extensive screening of at risk subjects.
She needed immediate care and I escorted her over to the mobile medical unit for more extensive screening.
The eventual development of potential drugs for therapy involves extensive screening of the drugs for effects throughout the body.
In polyploids the effect of mutations in single homoeologues is often masked by inherent genetic redundancy; therefore forward genetic screening for mutations requires extensive screening based on effective isoenzymatic or molecular markers.
Development of murine mAbs for robust and extensive screening of FFPE samples coupled with the detection of anti-tumour activity in novel indications provide rationale for expanding the application of SGN-75 for the treatment of multiple CD70 expressing cancers.
All subjects aged 55-74 years and random 5-10% samples of the other age groups who attended the first examination were invited to a second visit (Phase 2) for a more extensive screening, and 7965 subjects attended (93% of those invited at Phase 1).
We should make effort to strengthen the health education and perform extensive screening for the relatives of GC patients, especially for the first- and second-degree relatives, in order to detect GC earlier for them.
Our results highlight that a reliable species identification, followed by an extensive screening for a 'best strain' is an essential prerequisite for the proper identification of bioactive material.
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CEO of Professional Science Editing for Scientists @ prosciediting.com