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GWAS data will be used for exploratory analyses to identify any genes associated with stress and CVD.
For exploratory analyses, a composite binary score of depression was created using a Boolean OR operator approach (Pan et al, 2011) based on self-reported depressive symptoms (Ware and Sherbourne, 1992), physician-diagnosed depression, and antidepressant use whenever these information was available between 1986 and 2008.
Visualization functionality for model performance and for exploratory analyses of the data is provided.
Rectangular bounds were employed by Lindsay et al. (2010), and a convex hull with a ~1 km buffer zone was employed for exploratory analyses by Le Corvec et al. (2013a).
For exploratory analyses, the ATP cohort was split into two follow-up periods: follow-up over study months 3 9 (and3–9) and study months 3 14 (ATP3 14).
ACSL3 was chosen for subsequent assessment of the relationships between prenatal PAH exposure and gene 5'-CGI methylation status and for exploratory analyses of PAH exposure status and asthma classification in a larger sample of 56 children from the CCCEH cohort.
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In the factor analyses based on tetrachoric correlations, the dichotomous diagnoses were recalculated into continuous variables (see methods chapter), i.e. the illness data used for the exploratory analyses also reflect predispositions for illnesses as assumed by correlations between diagnosis groups.
Patient responses were assessed at week 24 for the primary analyses and at week 48 for the exploratory analyses.
Most of our comparisons involved high-dimensional data, and we therefore used FDR for our exploratory analyses, an analytical method that obviates the need for multiple corrections when using high-dimensional data [ 11].
For these exploratory analyses, p < .05 was utilized as the critical alpha to identify target symptoms of interest for future investigation of this intervention, recognizing the multiple testing might increase our type I error.
As for the exploratory analyses, baclofen's effects to increase alcohol sedation and to reduce alcohol consumption were limited to those individuals with DRD4 ≥ 7 repeats (DRD4L).
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