For example, the recommended comparator for a health economic analysis is a TAU control [ 70], while an active alternative treatment is likely to provide the most information for studies investigating mechanisms of action [e.g., [ 71]].
For example, the hypothetical common comparator "C" can indirectly link comparators of interest "A" and "B" in Trial 1 comparing interventions "A" versus "C" and Trial 2 comparing "B" versus "C".
For example, if the comparator instrument intends to measure physical activity (PA), it should be described which construct exactly it aims to measure.
For example, the use of a constant comparator in all but one study [ 65] suggests that they are unlikely to have used optimal designs [ 52].
Earlier studies conducted by Henry and colleagues [ 25] established a comparative toxicity range for a select group of drugs (using ibuprofen as the reference comparator); for example, the relative risk (RR) for aspirin was found to be 1.6, for diclofenac it was 1.8, for naproxen it was 2.2, and for ketoprofen it was 4.2.
There is little merit in creating a matching placebo or masking a comparator, when for example, the active is contained in a silver aluminium blister strip whereas white plastic blister has been used to package the placebo.
For example, the motor activity domain of the MSAT exhibited only weak correlations with the comparator (the VICS calmness scale).
For example, the critical transferability factors that have been proposed seem to focus on issues of study quality, transparency of methods, the level of reporting of methods and results, and the applicability of the treatment comparators to the target country.
For example, the kitchen.
