Sentence examples for for example increasing the lipophilicity of from inspiring English sources
For example, increasing the lipophilicity of drugs can enhance their capacity to cross the BBB although it often requires an increase in their size which limits the cell penetration capacity [ 99].
A number of prodrugs were prepared to improve the bioavailability of adefovir by increasing the lipophilicity of the compound.
Another gel using a nanostructured lipid carrier improved diffusion through the epidermis compared to traditional ibuprofen gel formulation by increasing the lipophilicity of ibuprofen [65].
A trifluoromethyl group usually increases the lipophilicity of a molecule, improving its transport characteristics in vivo.
Lipophilicity was thought to be positively correlated with log BB; that is, increase the lipophilicity of a molecule will increase the BBB penetration of the molecule.
In this study, we aimed to increase the lipophilicity of KTP by amidation and to evaluate the analgesic efficacy of a new KTP derivative (KTP-amide – KTP-NH2).
The substitution of the hydroxy with the methoxy groups increases the lipophilicity of pterostilbene over the resveratrol, which results in high bioavailability.
Aside from disfavouring DNA binding, the employment of more extended aromatic ancillary ligands would increase the lipophilicity of the final complex, thus favouring binding to lipid-based structures.
This affirmation reveals that electrons donating or withdrawing groups in molecules increase the lipophilicity of the compounds, which alters the permeability across the bacterial cell membrane [ 27].
It is well documented that increasing the lipophilicity, increases the diffusion through the lipid domain, thus, increasing the efficacy of the antimycobacterial agent [28 31].
The substitution of a hydrogen for a bromine atom actually increases the lipophilicity, giving 5-Br-DMT a pharmacokinetic edge over its close relatives DMT and bufotenine when partitioning into the brain.
