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For example, increasing the expression of an unnecessary protein in E. coli leads to a linear reduction in growth rate [ 4, 5].
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For example, SRSF1 increases the expression of a shorter oncogenic S6K1 isoform capable of transforming immortal mouse fibroblasts [ 65].
IS elements can influence gene expression depending upon the sites of insertion, for example, IS6110 increases the expression of neighboring genes which are involved in virulence [ 45].
For example, miR-10A can bind the 5′ untranslated region (UTR) of the mRNA transcript for several ribosomal genes, increasing the expression of these genes [3].
For example, DAC may increase the expression of some associated protein that enhances NALP1 expression in colon cancer.
For example, increased expression of the GABA-synthesizing enzyme glutamate decarboxylase (GAD) has been found in the hippocampus of chronically epileptic rats [6].
For example, increased expression of the lincRNA HOTAIR was found in primary and metastatic breast tumors [117].
For example, increased expression of CTS D was detected in the lungs of mice exposed to cigarette smoke [ 27].
Multiple mechanisms can lead to a higher grade of independence from exogenous growth stimuli, for example, increased expression of receptors and ligands or mutated constitutive active receptors.
For example, elimination of Hdac3 in postnatal liver cells increased the expression of Ppar-gamma 2 target genes and caused lipid accumulation, hepatocyte hypertrophy and hepatomegaly [31].
For example, increased expression and cytoplasmic localization of SAM68 correlated with clinical outcomes and prognosis for patients with breast cancer.
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