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The traditional method, used for example in the determination of the structure of DNA, is to produce a crystal form of the substance to be studied, then blast it with x-rays.
At the operating point of current devices, real gas effects already become relevant, for example in the determination of mass flow rates.
Systematic corrections involve uncertainties of their own, for example in the determination of the values of constants, and these uncertainties are assessed through secondary experiments involving further theoretical and statistical assumptions.
For example, in the determination of grain size analysis wet sieving was adopted with about 500 g of air-dried crushed shale mixed with distilled water and calgon (deflocculating agent) stirred for about 20 min for effective dispersal of the soil grains.
Such an approach was employed, for example, in the determination of a lubricating additive, 2-hydroxyethyl linoleate, in diesel fuel by the internal standard method, using pentadecanoyl propanoate as the internal standard.
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Tooze also makes skilful use of modern parallels and counterfactual scenarios – asking, for example, whether the determination of the allies to continue the war in 1917 killed outright the possibility of a democratic alternative to the Bolsheviks.
As noted in [ 13], alternative applications can be found in molecular phylogenetics, for example in the context of estimating relative frequencies of different nucleotide substitutions or the determination of the fraction of invariant sites in a particular gene.
A quantitative determination of molecular weights is necessary for example in the case of kinetic studies [ 30].
The coefficient of determination (CoD) has significant applications in genomics, for example, in the inference of gene regulatory networks.
The latter point is an important criterion in many applications such as for example in the analysis of convergence of MD simulations [19] as well as of methods for protein structure determination [7], [9].
For example, the determination of antigen levels of uPA and PAI-1 in tissue extracts of primary breast cancer has entered clinical practice for risk-adapted, individual therapy decisions in patients with lymph node-negative disease [ 11, 26].
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