Additional work is needed to confirm its efficacy in selected populations of cows, for example in repeat-breeder cows [ 13].
For example, in a repeated presentation of auditory or visual stimuli, an unexpected object of equivalent duration appears to last longer.
However, Sanger sequencing via capillary gel electrophoresis is still commonly used to correct for errors in assembling the sequence data, for example in long repeats of DNA polymers.
This has significant impact for samples from individuals with congenital DM1, for example, in which the repeat tract can be beyond 4 kb in size, but the viscoelastic matrix can be optimized to allow the separation of larger DNA fragments by, for example, reducing the PVP viscosity 15-fold (not shown).
For example, in maize, tandem repeats form chromosomal knobs that reduce recombination rate in adjacent regions (see Ghaffari et al. 2013).
All versions have been pilot tested in a sample of women from a range of socioeconomic backgrounds, and were modified on the basis of pilot feedback on the formatting, content and language (for example, in response to repeated requests for more recipes, the number of recipes accompanying newsletters was doubled).
This occurs, for example, in correlated samples and repeated measure designs, such as matched-pair studies and time-series data.
The most frequently reported ageing-associated DNA methylation changes (for example in ELOVL2) that are repeated across tissues and study populations, thus implying programmed changes, are hypermethylation events.
For example, in Drosophila, direct terminal repeats of the functional pDv elements might have been derived from the pvB370 satellite DNA family through insertion of a tandemly repeated 36-bp transcription unit [ 47].
For example, in FSHD1, the proximal repeats of the D4Z4 array on the contracted 4q35 allele are significantly hypomethylated in both PBMCs and myogenic cells compared to the non-contracted allele or healthy controls [ 17].
The technology of long-read sequencing now offers different alternatives to solve genome assembly problems (for example, in complex regions involving repeated elements or segmental duplications) and haplotype phasing, which cannot be resolved adequately by short-read sequencing.
