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For example, a preclinical study demonstrated that upregulation of proangiogenic pathways, through increased expression of IL-8, contributed towards evasion of anti-angiogenic effects mediated by sunitinib (Huang et al, 2010).
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Preclinical study demonstrated that CombiHIVvac does not cause long-term changes in physiological, biochemical and morphological parameters in immunized animals and thus can be recommended for clinical trials.
In fact, several preclinical studies demonstrated the mediatory and modulatory role of KYNA for glutamate and its receptors in central and peripheral pain processing [23].
Indeed, preclinical studies demonstrated in vitro and in vivo cytotoxic activity against both myeloma cell lines and primary patient cells4.
While clinical studies show that a loss of the microvascular circulation precedes and may act as an initiating factor for the development of chronic rejection, preclinical studies demonstrate that improved microvascular perfusion during acute rejection delays and attenuates tissue fibrosis.
The initial impetus to develop TLR9 agonists as anticancer drugs came from several preclinical studies demonstrating antitumor activity in a wide variety of tumor models.
This has been alluded to in preclinical studies demonstrating the potential capacity for combination with HDAC inhibitors (De et al., 2014).
Preclinical studies demonstrate that bioengineered neocartilage survives allogeneic and xenogeneic transplantation, suggesting the utility of universal donor-derived neocartilage for joint repair.
This report summarizes preclinical studies demonstrating the time course and mechanism of Seprafilm degradation.
Preclinical studies demonstrate that ZA can decrease prostate cancer osteoblastic bone metastasis and tumor growth [59].
Preclinical studies demonstrate that, depending on the timing of the intervention, antibody effector functions mediated by the Fc region may not be required for efficacy [ 3, 29- 31].
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