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For example, a large trial of drotrecogin alfa (activated) will determine the efficacy of the drug in patients with a single organ failure or APACHE II score <25.
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Recently, it was announced that the TACT 2 trial has been funded and will provide further information in a large trial of chelation therapy for heart disease.
Researchers are now enrolling patients for a larger trial of 600 to 800 patients.
Consider, for example, a large jigsaw puzzle.
Without greater understanding of the existing variation (for example through a smaller-scale dosing RCT), there is a danger of investing in a large trial that is suboptimal (for example including a number of different dosing regimens), which may be a less efficient use of resources than deferring a definitive trial until we better understand the existing variation.
For example the two largest trials of high frequency oscillation are subtly different though often combined in meta-analysis.
This provides an instructive example of the need to develop a large trial in several stages.
For example, if a two-arm trial had 113 patients in one arm and 87 patients in the other, it was considered a large trial.
For example, a drug trial should mention side effects.
As concluded by the authors [ 1], a larger trial should demonstrate improved survival (for example, upon septic shock [ 3]).
For example, in a large randomised control trial published in the Annals of Internal Medicine in 2013, there was no detectable increase in skin ageing over four-and-a-half years in the daily sunscreen group.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com