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A wealthy businessman who is close to him -- and spoke anonymously to remain that way -- said there were in fact two Putins, a security agent and a democrat, struggling for equipoise.
A critical part of this process was establishing whether it was feasible and ethical to implement a meaningful intervention within a randomised controlled trial (RCT) framework; key to gaining acceptance for the study was assuring stakeholders that the control arm would receive 'usual care' and that there was a prima facie case for equipoise.
SDM has been called to ensure evidence-based patient choice, especially for equipoise situation [ 48].
Sometimes the requirement for equipoise might hinder important research to confirm the efficacy of current (but unproven) treatments.
The need for equipoise was discussed during two training sessions in the preparation phase of the study and reinforced during quarterly training sessions.
Most panelists voiced support for equipoise between treatment arms in the study, viewed it as an important trial, and felt that it should not be stopped.
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Although there are published methods to assess the quality of clinical practice guidelines [5], DSTs go further and address issues of equipoise for which patients need to deliberate about difficult choices [6].
The ideal position of equipoise for a trial is when both patient and clinician have no particular preference for alternative treatment strategies.
Undeniably the state of equipoise for many in the use of nebulised frusemide demands well designed clinical trials in target populations using reliable and valid measures of outcome.
Facilitators found that acceptance improved as more explanation was given and was better understood in the more highly educated groups; nevertheless the concept of equipoise for the counselling intervention was challenging to explain and may not have been fully understood.
11 There is as yet no sense of a level playing field for evaluation, so the criterion of equipoise, required for a randomised trial, is not attained.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com