Sentence examples for for enhanced specificity from inspiring English sources
With a quantitative understanding of dual-ligand liposome binding, the insights gained from this study can inform rational design of modular heteromultivalent nanoparticles for enhanced specificity to target tissue for the creation of more effective cancer treatments.
Using four shapes of nanoparticles (nanospheres, nanostars, nanocubes, and nanorods), we demonstrate that each shape provides a unique set of responses in the presence of different bacteria, which can be exploited for enhanced specificity of the biosensor.
The single-stranded linear probe constitutes the largest portion, among which TaqMan probe is the mostly widely used and many derivative probes are basically modified from the TaqMan probe for enhanced specificity at the price of increased design complexity and extra synthesis cost.
Previous research with LNA in other applications has shown interesting properties for molecular hybridization including enhanced specificity in allele-specific PCR.
Because of the mutation heterogeneity of lung cancer cells associated with acquired drug resistance, the search for novel anticancer agents with an enhanced specificity for cancer cells remains an urgent need in order to increase the potency of chemotherapy [ 3].
These structures allow for the construction of models of DntR in complex with salicylate (Kd≅4 μM) and 2,4-dinitrotoluene that provide a basis for the design of mutant DntR with enhanced specificity for dinitrotoluenes.
A meta-analysis of FDG-PET literature[ 4] determined a 95% sensitivity and 97% specificity for PET in this setting, whilst a direct comparison of CT and FDG-PET reported sensitivity values of 52 and 91% for CT and PET respectively, along with enhanced specificity for PET (CT 80%, PET 100%)[ 5].
"Door-opening" conformational changes by phenylalanines within the hydrophobic pocket are revealed during lipid encapsulation by new crystal structures of bona fide apo-GLTP and GLTP complexed with N-oleoyl-glucosylceramide. The development of "engineered GLTPs" with enhanced specificity for select GSLs provides a potential new therapeutic approach for targeting GSL-mediated pathologies.
Bisubstrate analogs have the potential to provide enhanced specificity for protein kinase inhibition and tools to understand catalytic mechanism.
Using a structure-guided approach, we designed an O13 mutant with further enhanced specificity for H-trisaccharide.
It seems therefore attractive to design clustered TRAIL variants with enhanced specificity for tumor tissue.
