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The antagonist Ang-2 is known to downregulate Tie2 signaling, thereby preparing vascular endothelial cells for enhanced responsiveness to factors that cause destabilization of the endothelial barrier [12].
Additionally, CXCR4, the receptor for CXCL12, is overexpressed on CLL cells compared to normal B cells, and thus has the potential for enhanced responsiveness to CXCL12 signaling [5].
They should be simple, reliable, and valid with reduced administrative burden, which may integrate elements for enhanced responsiveness to patient concerns by using the platform by the published FDA guidance document.
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The state of lymphopenia following high-dose chemotherapy appears to provide a window of enhanced responsiveness to immunotherapy [45].
There is also evidence of enhanced responsiveness to IL-1β in hypertension.
Therefore, a partnership can eventually bear fruits of enhanced responsiveness, equity and efficiency in health care system.
For example, enhanced responsiveness of VS motivational neurocircuitry toward reward-predictive cues may bias behavior choice toward potentially-rewarding activities, irrespective of potential for a harmful outcome.
A trend for an enhanced responsiveness of the nuclear factor-κB pathway (P = 0.063, n = 39) was seen in mDCs from children with β-cell autoantibodies, which is possibly related to the reduced CCR2 expression, since CCR2 on mDCs was downregulated by nuclear factor-κB activating agents.
Thus, calcium – dependent adenylyl cyclase activity, which most likely reflects AC3 activity, does not account for enhanced AVP responsiveness in CD ET-1 KO IMCD.
There was no evidence for enhanced vasoconstrictor responsiveness to CCPA in LPS-treated rats, but DPCPX caused renal vasodilatation, consistent with endogenous adenosine mediating renal vasoconstriction under these conditions.
So, too, it is probable for OA because an increased incidence of spontaneous activity and enhanced responsiveness of joint nociceptors and dorsal horn neurones have been reported [ 10- 17].
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