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With this in mind, repeated inoculations of hMSCs in the tumors and possibly at different locations might be necessary for efficient therapy of large established tumors.
Indeed, migration of MSCs to target tissues and secondary lymphoid organs where they are able to educate immune cells is likely to be required for efficient therapy.
Biomarkers that can identify tuberculosis (TB) disease and serve as markers for efficient therapy are requested.
This could be associated with appropriate HIV RNA quantitation and drug resistance testing for efficient therapy.
Furthermore, another recent study demonstrated the necessity to administer 50 and 60 mg/kg twice-daily daptomycin regimens for efficient therapy of experimental osteomyelitis in rabbits [ 42].
Redundancy of growth factor signaling pathways makes angiogenesis a robust physiological function [ 10, 11], where targeting multiple pathways with drug combinations may be necessary for efficient therapy [ 12].
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The knowledge about mechanisms governing gene expression in tumor onset and progression appears essential for efficient therapies setting.
The obesity epidemic continues to spread throughout the world, and the search for efficient therapies to combat obesity has become a priority for health systems (Stein and Colditz, 2004).
Analyzing failure and success of immunotherapies in hematological malignancies, and in solid cancers, frequently elucidated the same requirements for an efficient therapy, i.e., the immune system seems to be most effective when mounting a complex immune response against a defined intruder.
Considering the available therapeutic options, the need for an alternative efficient therapy is overwhelming.
Defects in mitochondrial DNA often cause neuromuscular pathologies, for which no efficient therapy has yet been developed.
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CEO of Professional Science Editing for Scientists @ prosciediting.com