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Therefore, the targeting of ASB9 to uMtCK is quite proper for efficient regulation of cell growth.
The combinatorial multi-site interaction mode may also be advantageous for efficient regulation of ANK repeats/target interactions.
Warren and ten Wolde (2004) [ 5] find a substantially reduced distance between operons in such regulatory pairs, suggesting an evolutionary pressure to reduce such distances for efficient regulation.
First, a relatively high expression level of the transcription factors is required for efficient regulation of their target genes, unless other proteins occupy the nonfunctional quasi-specific sites.
In a fertilized egg, global DNA demethylation followed by remethylation occurs to reprogram the maternal and paternal genomes for efficient regulation of gene expression.
Balanced activation of MR and GR is considered essential for efficient regulation of the stress response which is crucial for the maintenance of homeostasis and mental health (Oitzl et al. 2010).
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It has been hypothesized that the higher copy numbers are required in free-living nematodes for more efficient regulation of gene expression and for responding better and more quickly to environmental factors such as temperature, nutrient availability, metal ions or pH [ 10].
Methods for simple and efficient regulation of metabolic pathway genes are essential for maximizing product titers and conversion yields, and for minimizing the metabolic burden caused by heterologous expression of multiple genes often in the operon context.
The concept that coexpressed small RNAs may synergistically target protein complexes for a more efficient regulation is of course not limited to animal miRNAs.
Some authors argue that the fact that some genes are located within a single co-transcribed region selects for a more efficient regulation [ 51].
It has been proposed that the cytosolic enzymes involved in the sequential methylation of Chrysosplenium flavonoids are organized on the surface of a multienzyme aggregate, thus allowing for a more efficient regulation of the pathway as a whole [ 16].
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