Sentence examples for for efficacious exposure from inspiring English sources

BMS-927711 antagonizes CGRP-induced increases in marmoset facial blood flow (a surrogate marker for intracranial artery dilation) with 75% inhibition at ~700 nM, a surrogate for efficacious exposure.

Based on the pharmacokinetic results in this study, a daily dose of 160 mg for 3 days is able to achieve an efficacious exposure AUC0 24 of at least 1,800 ng · h/ml, which is equivalent to the efficacious dose in mice, while a daily dose of 400 mg for 3 days or a single dose of 800 mg is able to maintain a total plasma concentration greater than the MIC for 6 days.

If the product is proven to be efficacious, exposure will most likely continue on a long term basis.

Therefore, we suggest that in many cases, the reduction in in vitro activities of the XTENylated ligands may be more than compensated for by the longer efficacious exposures due to the extensions in biological half-life, and we can also predict an increase in in vivo potency for the T-20-XTEN conjugates due to their prolonged exposure in the body.

As a result, in order to achieve efficacious exposures, this younger group might need a higher dosage of daptomycin.

The disinfection method proposed here shows the potential for efficacious application to this species.

"We continue to search for efficacious alternatives to formaldehyde in hardeners," Schwartz wrote.

These findings stress the pressing need for efficacious, systemic chemotherapy for patients with inoperable HCC.

Translational PK-PD modeling can support the design of FIH studies by providing estimates of efficacious target exposures, associated dose regimens, and guidance in selection of biomarker and optimal sampling time points for exposure and biomarkers.

The results of the mediation analysis have implications for developing efficacious interventions for African American MSM.

This mode of protection suggested that the anti-HIV receptor antibody is efficacious for prophylaxis after exposure to HIV and for prevention of maternal transmission and may be an effective antiretroviral agent for treatment.