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Conformity with performance measures ranged from a median of 6.5% for the use of intravenous tPA (tissue-type plasminogen activator) to 81.8% for early use of antithrombotics.
Dipeptidyl peptidase-4 inhibitors are good candidates for early use as they are efficacious in combination with metformin, show weight neutrality and a low risk of hypoglycaemia.
For asthma and wheeze at 6 years, an association was obtained for use of paracetamol between 5 and 6 years of age (>19 times), but not for early use.
Nevertheless, an example of successful bellows ventilation has been reported by Fell in 1891 in a clinical trial [ 1]. James Leroy d'Etiolles emphasized the need for early use of the bellows and recommended in 1828 a graduated bellows according to the patient size to reduce hyperventilation with high volumes which may induce barotrauma [ 1].
Dipeptidyl peptidase-4 (DPP-4) inhibitors increase the availability of endogenous glucagon-like peptide 1 (GLP-1) and are good candidates for early use in combination with metformin as they are oral agents increasing glucose-sensitive insulin secretion with a very low risk of hypoglycaemia 1.
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Now a new trial offers scant support for earlier use of radio frequency ablation to treat atrial fibrillation.
In the first place, it relies on the notion that there are reliably enough "golden years" in retirement that some of them can be traded in for earlier use.
Another advantage is the fact that the created tool gives the opportunity for earlier use.
Because tumour angiogenesis occurs in a very early stage of carcinogenesis, there is a strong rationale for earlier use of bevacizumab in the adjuvant setting [ 83].
For the (not very important) recent mobile phone use, self reports seem to be fairly accurate, but for earlier use, no data on reliability are available.
The population consisted of individuals who were late adopters of secure email use with clinicians and likely differed in systematic ways from those who opted for earlier use, which may limit the generalisability of the results.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com